Essential Tremor Feasibility Study

Enrolling

Study Purpose: We are studying how low-intensity ultrasound affects brain activity and tremor symptoms in people with essential tremor. Please note this is not a treatment study—while the ultrasound may have temporary effects on your tremor, this is not expected to provide lasting clinical benefit. The information we collect will help us develop better research tools and advance the understanding and treatment of essential tremor.

The Technology

Low-intensity ultrasound uses focused sound waves, similar to those used in medical imaging, to deliver precise pulses of energy to specific regions of the brain. The sound waves are generated by a device placed on your head, and the energy levels used are low and within international safety guidelines. While ultrasound is commonly used in medical applications, its use in this study is experimental and has not been approved by the FDA for treatment.

The magnetic resonance imaging (MRI) component of our study is crucial for ensuring accurate and precise application of low-intensity ultrasound. MRI provides detailed, real-time images of your brain, allowing us to target specific regions with high precision. The MRI scanner uses magnetic fields and radio waves to create images – there is no radiation involved. During the experiment, you will be in the MRI scanner while we deliver the low-intensity ultrasound. The combination of low-intensity ultrasound with MRI allows us to both precisely target the stimulation and observe its effects on brain activity.

Inclusion Criteria

We will recruit up to 150 English-speaking male and female subjects between the ages of 22-80 with a primary diagnosis of essential tremor.

Study Description: This multi-year research study is designed to evaluate how targeted sound waves affect specific regions of the brain while participants are in an MRI scanner. Participants may also be asked to complete additional questionnaires between visits.

Participant Time Commitment: Participation involves multiple sessions over a period of approximately 4–8 weeks. Each session is expected to last about 2–3 hours.

Study Compensation: You will be compensated $100/hour. Parking costs will be reimbursed if you drive to the study site. Study-related travel costs will be covered (e.g., rideshares, tolls, airfare, hotel).

Study Sites: Berkeley, CA and Mission Bay, San Francisco, CA

Study Interest Form

By completing and submitting this form, you will be added to the Participant Registry and agree to receive information about current or upcoming studies that may match your interests. Signing up for the Participant Registry does not guarantee enrollment in research studies or clinical trials.

Are you filling out this form for yourself or on someone else's behalf? ^*

Legal First Name ^*

Preferred Name

Legal Last Name^*

Email ^*

Phone Number ^*

Location ^*

Date of Birth ^*

Sex ^*

Race

How did you hear about us? ^*

Do you have any diagnosed medical conditions? If yes, please select them. ^*

Would you be interested in participating in studies related to the condition(s) listed above? ^*

Consent & Disclaimers

By checking this box, I agree to have my data added to the Participant Registry in accordance with the . I may be contacted about participation in current and/or future research studies. ^*

I understand that submitting this form does not guarantee enrollment in any studies. ^*

^* required fieldBy submitting this form, you agree to allow your data to be used by Nudge according to our Terms of Service.